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Oct. 5, 2025, 12:13 p.m. -  side effects cjc 1295 ipamorelin
Ipamorelin is a synthetic growth hormone releasing peptide that has gained popularity among bodybuilders, athletes, and individuals seeking anti‑aging benefits due to its ability to stimulate the secretion of growth hormone in a more selective manner than older peptides such as GHRP‑2 or GHRP‑6. Although it is generally regarded as having a favorable safety profile compared with other stimulators, recent clinical observations and case reports have raised concerns about potential adverse effects, particularly the risk of malignant transformation in susceptible tissues. The peptide’s mechanism of action involves binding to the ghrelin receptor (GHSR) on pituitary somatotrophs, which triggers the release of growth hormone. This hormone then promotes the production of insulin‑like growth factor 1 (IGF‑1), a potent mitogen that can stimulate cellular proliferation and inhibit apoptosis. In patients with pre‑existing tumors or genetic predispositions to cancer, chronic elevation of IGF‑1 may accelerate tumor growth or aid in the transition from benign to malignant lesions. Consequently, long‑term users of ipamorelin should be monitored for changes in circulating IGF‑1 levels and screened for early signs of neoplastic development. Clinical data on ipamorelin’s oncogenic potential remain limited

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