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Oct. 5, 2025, 12:34 p.m. -  benefits and side effects
Tesamorelin is a synthetic peptide that has been developed to help reduce excess abdominal fat in certain patient populations, particularly those living with HIV who experience lipodystrophy. It works by stimulating the release of growth hormone from the pituitary gland, which then triggers downstream effects on metabolism and adipose tissue distribution. In addition to its primary use for visceral fat reduction, tesamorelin is sometimes prescribed off‑label for other conditions such as growth hormone deficiency in adults or certain metabolic disorders. Benefits The most well documented benefit of tesamorelin therapy is a significant decrease in visceral adipose tissue (VAT). Clinical trials have shown reductions ranging from 10 to 20 percent over the course of six months to one year. Because VAT is closely linked to insulin resistance, dyslipidemia and cardiovascular risk, patients often experience improved glycemic control, lower triglyceride levels and decreased blood pressure as a secondary effect. In HIV‑positive individuals, reducing visceral fat can also alleviate discomfort from abdominal swelling and improve overall body image. Other potential benefits include modest increases in lean body mass, improvements in quality of life scores related to physical functioning, and a lower incidence of metabolic complications such as type 2 diabetes mellitus. Some patients report better sleep patterns and reduced fatigue after beginning therapy, although these effects are not universally observed. Dosage Tesamorelin is typically administered via subcutaneous injection once daily at a dose of 2 mg per day. The injection site can be the abdomen, thigh or upper arm, depending on patient preference and tolerability. Patients should be instructed to rotate sites to minimize local skin irritation. It is important to maintain a consistent schedule

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